A New Feature Selection Method based on Intuitionistic Fuzzy Entropy to Categorize Text Documents

Selection of highly discriminative feature in text document plays a major challenging role in categorization. Feature selection is an important task that involves dimensionality reduction of feature matrix, which in turn enhances the performance of categorization. This article presents a new feature selection method based on Intuitionistic Fuzzy Entropy (IFE) for Text Categorization. Firstly, Intuitionistic Fuzzy C-Means (IFCM) clustering method is employed to compute the intuitionistic membership values. The computed intuitionistic membership values are used to estimate intuitionistic fuzzy entropy via Match degree. Further, features with lower entropy values are selected to categorize the text documents. To find the efficacy of the proposed method, experiments are conducted on three standard benchmark datasets using three classifiers. F-measure is used to assess the performance of the classifiers. The proposed method shows impressive results as compared to other well known feature selection methods. Moreover, Intuitionistic Fuzzy Set (IFS) property addresses the uncertainty limitations of traditional fuzzy set

Synthesis, spectral characterization and some biological studies of transition metal complexes with Schiff base ligand containing N,O and S as donor atoms

Transition metal complexes of Cu(II), Co(II), Ni(II), Zn(II), Cd(II) and Mn(II) have been synthesized with the Schiff base ligand 5-Sub-N-(2-mercaptophenyl)salicylideneimine. Elemental analysis of these complexes suggest that these metal ions forms complexes of type ML(H2O)stoichiometry for Cu(II), Co(II), Ni(II), Zn(II), Cd(II) and Mn(II). The ligand behaves as tridentate and forms coordinate bonds through O, S and N atoms. Magnetic susceptibility, IR, UV – Visible, Mass and ESR spectral studies suggest that Cu(II), Ni(II) complexes posses square planar geometry, whereas Co(II), Zn(II), Cd(II) and Mn(II) complexes posses tetrahedral geometry. The complexes were tested for their antimicrobial activity against the bacterial strains Staphylococcus aureus and Bacillus subtilis.The Schiff base metal complexes evaluated for their antifungal activity against the fungi A. niger and C. oxysporum. The DNA cleavage studies of Schiff base complexes werestudied using Calf – Thymus DNA by agarose gel electrophoresis method

ANTIEPILEPTIC ACTIVITY OF SOME NOVEL SUBSTITUTED FLUORO BENZOTHIAZOLE DERIVATIVES

Objective: The aim of the study is to investigate and to reveal the antiepileptic activity of fluoro substituted benzothiazole derivatives (FBTDs) in experimental induced epilepsy in mice.Methods: The acute oral toxicity was determined as per OECD guideline 423 and minimum effective dose was also determined for pharmacological screening. The antiepileptic activity of FBTDs was studied against maximal electroshock (MES) and strychnine (1 mg/kg, s. c.) induced seizures in mice.Results: In MES test, the duration of tonic hind limb extension was significantly reduced by all FBTDs at a dose of 100 mg/kg except, P-3, and OX-9 whereas in strychnine induced model, the seizure latency was sustained by all FBTDs at a dose of 100 mg/kg except P-4. P-7 and OX-9.Conclusion: The novels synthesized FBTDs shown very good activity and lead a route for further studies in this particular molecule.Â

Spectrophotometric Determination of Mycophenolate Mofetil as Its Charge-Transfer Complexes with Two π-Acceptors

Two simple, selective, and rapid spectrophotometric methods are described for the determination of mycophenolate mofetil (MPM) in pure form and in tablets. Both methods are based on charge-transfer complexation reaction of MPM with p-chloranilic acid (p-CA) or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in dioxane-acetonitrile medium resulting in coloured product measurable at 520 nm (p-CA) or 580 nm (DDQ). Beer's law is obeyed over the concentration ranges of 40–400 and 12–120 μg mL−1 MPM for p-CA and DDQ, respectively, with correlation coefficients (r) of 0.9995 and 0.9947. The apparent molar absorptivity values are calculated to be 1.06 × 103 and 3.87 × 103 L mol−1 cm−1, respectively, and the corresponding Sandell's sensitivities are 0.4106 and 0.1119 μg cm−1. The limits of detection (LOD) and quantification (LOQ) are also reported for both methods. The described methods were successfully applied to the determination of MPM in tablets. Statistical comparison of the results with those of the reference method showed excellent agreement. No interference was observed from the common excipients present in tablets. Both methods were validated statistically for accuracy and precision. The accuracy and reliability of the methods were further ascertained by recovery studies via standard addition procedure

Antihyperlipidemic activity of Chloroxylon swietenia in triton WR1339 induced hyperlipidemia

Background: Medicinal herbs are beneficial and effective either in the management and prevention of several metabolic disorders, associated with hyperlipidemia, hypertension and insulin resistance which increases the cardio-metabolic risk and demands for the life time therapy. Current allopathic medicines are expensive and reported with several adverse effects and hence, finding of a suitable herbal medicine for hyperlipidemic disorders is very important.Methods: Thirty albino rats weighing 200-230g were randomly divided into 5 groups were rendered hyperlipidemia with a single dose of triton WR 1339. Normal control, positive control, standard, aqueous and ethanolic extract groups were treated with tween-80, tween-80, atorvastatin, aqueous and ethanolic extracts of Chloroxylon swietenia respectively for seven days. At the end of the study, blood was collected for estimation of the lipid profile.Results: Both the aqueous and ethanolic extract groups significantly reduced the TG and VLDL levels.Conclusions: The extracts exhibited remarkable activity on one or either parameter of the lipid profile. It could be due to the presence of alkaloids, steroids, flavonoids, coumarins and phenols in the extracts

N-{3-[2-(4-Fluoro­phen­oxy)eth­yl]-2,4-dioxo-1,3-diaza­spiro­[4.5]decan-7-yl}-4-meth­oxy­benzene­sulfonamide

In the title compound, C23H26FN3O6S, the two terminal aromatic rings form a dihedral angle of 49.26 (12)°. The cyclo­hexane ring adopts a chair conformation and the five-membered ring is essentially planar, with a maximum deviation from planarity of 0.0456 (19) Å. The dihedral angles between the five-membered ring and the meth­oxy­benzene and fluoro­benzene rings are 33.56 (11) and 81.94 (12)°, respectively. The crystal structure displays N—H⋯O hydrogen bonds as well as weak inter­molecular C—H⋯O inter­actions

A New Feature Selection Method based on Intuitionistic Fuzzy Entropy to Categorize Text Documents

Selection of highly discriminative feature in text document plays a major challenging role in categorization. Feature selection is an important task that involves dimensionality reduction of feature matrix, which in turn enhances the performance of categorization. This article presents a new feature selection method based on Intuitionistic Fuzzy Entropy (IFE) for Text Categorization. Firstly, Intuitionistic Fuzzy C-Means (IFCM) clustering method is employed to compute the intuitionistic membership values. The computed intuitionistic membership values are used to estimate intuitionistic fuzzy entropy via Match degree. Further, features with lower entropy values are selected to categorize the text documents. To find the efficacy of the proposed method, experiments are conducted on three standard benchmark datasets using three classifiers. F-measure is used to assess the performance of the classifiers. The proposed method shows impressive results as compared to other well known feature selection methods. Moreover, Intuitionistic Fuzzy Set (IFS) property addresses the uncertainty limitations of traditional fuzzy set

Synthesis and evaluation of novel imidazo[4,5-c]pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis

The current study involves the synthesis of novel imidazo4{,}5-cpyridine derivatives (IPD) containing amide/urea/sulfonamide. The synthesized compounds were evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. The pharmacological activities were determined by the objective to better understand their structure–activity relationship (SAR) for their in vitro antimycobacterial activity against M. tuberculosis. Some synthesized compounds showed significant activity against M. tuberculosis based on the agar dilution method. Among the forty-one compounds screened{,} compounds 21{,} 22 and 23 were found to be the most active compounds against M. tuberculosis. In the in vivo animal model{,} 21{,} 22 and 23 decreased the bacterial load in lung and spleen tissues at the dose of 50 mg kg−1 body weight

Synthesis and evaluation of 3-(2,4-{Dioxo}-1,3,8-triazaspiro4.6]undec-3-yl) methyl]benzonitrile derivatives as potential anticonvulsants

New 3-(2,4-dioxo-1,3,8-triazaspiro4.6]undec-3-yl)methyl]benzonitrile derivatives 8-37 were synthesized and their pharmacological activities were determined with the objective to better understand their structure-activity relationship (SAR) for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) and pentylenetetrazole (PTZ) test. Compounds 11, 18, 31, and 32 showed significant and protective effect on seizure, when compared with the standard drug valproate. The same compounds were found to exhibit advanced anticonvulsant activity as well as lower neurotoxicity than the reference drug. From this study, it is quite apparent that there are at least three parameters for the activity of anticonvulsant drugs, that is, a lipophilic domain, a hydrophobic center, and a two-electron donor. A series of 3-(2,4-Dioxo-1,3,8-triazaspiro4. 6]undec-3-yl)methyl]-benzonitrile derivatives 8-37 were synthesized and evaluated for their anticonvulsant activity. The most promising compounds 11, 18, 31, and 32 showed significant and protective effects on seizure. The novel anticonvulsant agents include essential pharmacophoric elements in their structure